m [dot] woodin (at)utoronto [dot] ca
Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Canada M5S 3G5
Dr. Woodin's long-term goal as an independent investigator is to understand the cellular mechanisms and the functional significance of inhibitory synaptic plasticity. She is interested in the mechanisms that underlie GABAergic synaptic plasticity, as well as the adaptive significance this plasticity imparts. Using combined electrophysiological recordings with Ca2+-imaging from hippocampal cultures and slices we aim to determine the following: (1) the mechanisms underlying coincident pre- and postsynaptic activity-induced modification of hippocampal GABAergic synapses; (2) whether inhibitory plasticity is sufficient for the expression of pathway-restricted LTP in area CA1 of the rat hippocampus; and (3) how inhibitory synaptic plasticity regulates pyramidal neuron spiking in the rodent hippocampus.