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David S Guttman

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Full Professor
Director, Centre for the Analysis of Genome Evolution & Function, and Associate Chair for Research
Canada Research Chair in Comparative Genomics
Education: 
Ph.D., State University of New York at Stony Brook, 1994
Department: 
Cell & Systems Biology
Research Areas: 
Systems Biology & Bioinformatics, Functional Genomics & Genetics, Microbiology, Molecular Evolution, Plant Biology
Graduate Programs: 
Cell & Systems Biology, Laboratory Medicine & Pathobiology, Genome Biology & Bioinformatics, Ecology & Evolutionary Biology
Office phone: 
416-978-6865
Lab phone: 
416-946-7121
Fax: 
416-978-5878
URL: 
http://labs.csb.utoronto.ca/guttman
Office: 
ESC 4041
Lab: 
ESC 4039

david [dot] guttman (at)utoronto [dot] ca

Address: 

Department of Cell & Systems Biology
University of Toronto
25 Willcocks Street
Toronto, Ontario
Canada M5S 3B2

Research: 

We use a range of comparative, evolutionary and functional genomic approaches to study the evolution of host specificity and virulence in pathogenic bacteria. We are specifically interested in identifying the genetic determinants of host specificity, and determining what factors determine if a bacterial-host interaction is benign or results in disease. Our work will lead to a better understanding of where the genetic potential for virulence originates, and how is it maintained in bacterial populations. We work with the agriculturally important plant pathogen Pseudomonas syringae, and the opportunistic human pathogen Pseudomonas aeruginosa.

  • Selected publications:
2011
O'Brien, H., Thakur, S., Guttman, D. (2011).  Evolution of Plant Pathogenesis in Pseudomonas syringae: A genomic perspective. . Annual Review of Phytopathology . 49, 1–21.
Austin, R.S., Vidaurre, D., Stamatiou, G., Breit, R., Provart, N.J., Bonetta, D., Zhang, J., Fung, P., Gong, Y., Wang, P.W., McCourt, P., Guttman, D.S. (2011).  Next-Generation Mapping of Arabidopsis Genes. The Plant Journal. 67, 715–725. Abstract
2006
Sarkar, S., Gordon, J., Martin, G., Guttman, D. (2006).  Comparative Genomics of Host-Specific Virulence in Pseudomonas syringae. Genetics. 174, 1041-1056. Abstract
Stavrinides, J., Ma, W., Guttman, D. (2006).  Terminal Reassortment Drives the Quantum Evolution of Type III Effectors in Bacterial Pathogens. PLoS Pathogens. 2(10), e104. Abstract
2005
Hwang, M., Morgan, R., Sarkar, S., Wang, P., Guttman, D. (2005).  Phylogenetic characterization of virulence and resistance phenotypes in Pseudomonas syringae. Applied and Environmental Microbiology. in press. Abstract
Lindeberg, M., Stavrinides, J., Chang, J., Alfano, J., Collmer, A., Dangl, J., Greenberg, J., Mansfield, J., Guttman, D. (2005).  Unified nomenclature and phylogenetic analysis of extracellular proteins delivered by the type III secretion system of the plant pathogenic bacterium Pseudomonas syringae. Molecular Plant-Microbe Interactions. 18(5), 275-282. Abstract
2004
Stavrinides, J., Guttman, D. (2004).  Mosaic evolution of the Severe Acute Respiratory Syndrome coronavirus.. Journal of Virology. 78(1), 76-82. Abstract
Stavrinides, J., Guttman, D. (2004).  Nucleotide Sequence and Evolution of the Five-Plasmid Complement of the Phytopathogen Pseudomonas syringae pv. maculicola ES4326. JOURNAL OF BACTERIOLOGY. 5101-5115. Abstract
Wang, P., Chu, L., Guttman, D. (2004).  Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112.. Journal of Bacteriology. 186(2), 400-410. Abstract
Stavrinides, J., Guttman, D. (2004).  Nucleotide Sequence and Evolution of the Five-Plasmid Complement of the Phytopathogen Pseudomonas syringae pv. maculicola ES4326. Journal of Bacteriology. 186 (15), 5101-5115. Abstract
Gropp, S., Guttman, D. (2004).  The PCR amplification and characterization of entire Pseudomonas syringae hrp/hrc clusters.. Molecular Plant Pathology. 5(2), 137-140. Abstract
Sarkar, S., Guttman, D. (2004).  The evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen.. Applied and Environmental Microbiology. 70(4), 1999-2012. Abstract
Guttman, D. (2004).  Plants as models for the study of human pathogenesis.. Biotechnology Advances. 22, 363-382. Abstract
Rohmer, L., Guttman, D., Dangl, J. (2004).  Diverse evolutionary mechanisms shape the type III effector virulence factor repertoire in plant pathogenic Pseudomonas syringae. Genetics. 167, 1341-1360. Abstract
2002
Guttman, D., Vinatzer, B., Sarkar, S., Ranall, M., Kettler, G., Greenberg, J. (2002).  A functional screen for the type III (Hrp) secretome of the plant pathogen Pseudomonas syringae.. Science. 295, 1722-1726. Abstract
2001
Guttman, D., Greenberg, J. (2001).  Functional analysis of type III effectors of Pseudomonas syringae using a single copy genomic integration system.. Molecular Plant-Microbe Interactions. 14(2), 145-155. Abstract
1998
Guttman, D., Charlesworth, D. (1998).  An X-linked gene with a degenerate Y-linked homologue in a dioecious plant.. Nature. 393, 263-266. Abstract
1997
Guttman, D. (1997).  Recombination and clonality in natural populations of Escherichia coli.. Trends in Ecology and Evolution. 12, 16-22. Abstract
1996
Guttman, D., Wang, P., Wang, I., Bosler, E., Luft, B., Dykhuizen, D. (1996).  Multiple infection of Ixodies scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis.. Journal of Clinical Microbiology. 34, 652-656. Abstract
1994
Guttman, D., Dykhuizen, D. (1994).  Clonal divergence in Escherichia coli as a result of recombination, not mutation.. Science. 266, 1380-1383. Abstract
Guttman, D., Dykhuizen, D. (1994).  Detecting selective sweeps in naturally occurring microorganisms.. Genetics. 138, 993-1003. Abstract