David S Guttman
david [dot] guttman (at)utoronto [dot] ca
Department of Cell & Systems Biology
University of Toronto
25 Willcocks Street
Canada M5S 3B2
We use a range of comparative, evolutionary and functional genomic approaches to study the evolution of host specificity and virulence in pathogenic bacteria. We are specifically interested in identifying the genetic determinants of host specificity, and determining what factors determine if a bacterial-host interaction is benign or results in disease. Our work will lead to a better understanding of where the genetic potential for virulence originates, and how is it maintained in bacterial populations. We work with the agriculturally important plant pathogen Pseudomonas syringae, and the opportunistic human pathogen Pseudomonas aeruginosa.