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Dinesh Christendat

christendat.jpg
Associate Professor
Education: 
Ph.D., Concordia University, 1998
Department: 
Cell & Systems Biology
Research Areas: 
Microbiology, Plant Biology, Proteomics
Graduate Programs: 
Cell & Systems Biology, Genome Biology & Bioinformatics
Office phone: 
416-946-8373
Lab phone: 
416-946-8436
Fax: 
416-978-5878
URL: 
http://labs.csb.utoronto.ca/christendat
Office: 
ESC 4052
Lab: 
ESC 4045

dinesh [dot] christendat (at)utoronto [dot] ca

Address: 

Department of Cell & Systems Biology
University of Toronto
25 Willcocks Street
Toronto, Ontario
Canada M5S 3B2

Research: 

Plant Biochemistry: Structural and Functional Proteomics of Metabolic Pathways. Genomics research has produced a wealth of new information which revealed that less than 50% of plant proteins have a known function. My lab focuses on functional characterization of these proteins using a number of synergistic technologies including protein crystallography, protein-protein interactions, protein-ligand complexes and enzyme kinetics. My group also studies enzymes of the shikimate pathway by protein crystallography and mechanistic enzymology.

  • Selected publications:
In Press
Edwards, A.M., Arrowsmith, C.H., Christendat, D., Dharamsi, A., Friesen, J.D., Greenblatt, J.F., Vedadi, M. (In Press).  Protein production for the crystallographers and NMR spectroscopists.. Nature Structural Biology. 7, 970-972.
2011
Fucile, G., DiBiase, D., Nahal, H., La, G., Khodabandeh, S., Chen, Y., Easley, K., Christendat, D., Kelley, L., Provart, N.J. (2011).  ePlant and the 3D Data Display Initiative: Integrative Systems Biology on the World Wide Web. PLoS ONE. 6(1), e15237. Abstract
2008
Fucile, G., Falconer, S., Christendat, D. (2008).  Evolutionary Diversification of Plant Shikimate Kinase Gene Duplicates.. PLoS Genet. 4(12), e1000292.
2000
Christendat, D., Yee, A., Dharamsi, A., Kluger, Y., Savchenko, A., Cort, J.R., et.al., (2000).  Structural Proteomics of an Archeon.. Nature Structural Biology. 9, 603-609.
Christendat, D., Saridakis, V., Dharamsi, A., Bochkarev, A., Pai, E.F., Arrowsmith, C.H., Edwards, A.M. (2000).  High-resolution structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.. J. Biol. Chem.. 275, 24608-24612.
Christendat, D., Yee, A., Dharamsi, A., Kluger, Y., Gerstein, M., Arrowsmith, C.H., Edwards, A.M. (2000).  Structural proteomics: prospects for high throughput sample preparation.. Prog. Biophys. Mol. Biol.. 73, 339-345.
1999
Christendat, D., Turnbull, J. (1999).  Identification of Groups involved in Binding Prephenate to Prephenate Dehydrogenase from E.coli.. Biochemistry. 38, 4782-4793.
1998
Christendat, D., Saridakis, V., Turnbull, J. (1998).  Use of Site-Directed Mutagenesis to Identify Residues Important for Each Reaction Catalyzed by Chorismate Mutase - Prephenate Dehydrogenase from E.coli.. Biochemistry. 37, 15703-15712.
1996
Christendat, D., Turnbull, J. (1996).  Identification of Active Site Residues of Chorismate Mutase - Prephenate Dehydrogenase from E.coli.. Biochemistry. 35, 4468-4479.