Malcolm Campbell

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Full Professor
Vice-Principal, Research, U of T Scarborough
Education: 
PhD - University of Guelph, 1991; MA - Oxford University, 1996
Department: 
Cell & Systems Biology
Research Areas: 
Molecular Biology & Biotechnology, Systems Biology & Bioinformatics, Cell & Developmental Biology, Functional Genomics & Genetics, Plant Biology
Graduate Programs: 
Cell & Systems Biology, Forestry, Developmental Biology, Genome Biology & Bioinformatics, Ecology & Evolutionary Biology
Office phone: 
416-208-4835
Lab phone: 
416-978-3543
Fax: 
416-208-4707
Office: 
AA 439
Lab: 
ESC 3058

malcolm [dot] campbell (at)utoronto [dot] ca

Address: 

Vice Principal, Research
University of Toronto at Scarborough
1265 Military Trail
Toronto, Ontario
Canada M1C 1A4

Research: 

Despite the incredible diversity in plant forms, the molecular mechanisms that control plant architecture are highly conserved across diverse genera. It is thought that the timing and localization of these mechanisms, in response to environmental and developmental cues, determine the overall structure of the plant body. My research team tests hypotheses aimed at understanding the molecular mechanisms that control plant architecture. Much of my group's work has focused on the regulation of aspects of plant growth and development that are critical in architectural design. This work has largely centred on an exploration of the molecular mechanisms that underpin the timing and localization of lignin biosynthesis. Lignins are complex three-dimensional polymers that reinforce specific plant cell walls and thereby impart strength that is important in supporting the plant body against gravity. The control of the timing and localization of lignin biosynthesis is important in establishing the architectural design of the plant body. My group focuses on the role of members of the MYB family of transcription factors in controlling the timing and localization lignin biosynthesis. As a complement to this work, my team has also been characterising mutant plants that accumulate lignins in tissues where they would not normally be found, in order to understand the mechanisms controlling the localisation of this important building material. Other work in my lab is aimed at understanding how members of the MYB family of transcription factors affect plant architecture beyond their role in the control of lignin biosynthesis.

2009
Wilkins, O., Nahal, H., Foong, J., Provart, N.J., Campbell, M.M. (2009).  Expansion and Diversification of the Populus R2R3-MYB Family of Transcription Factors. Plant Physiology. 149(2), 981-993. Abstract
Wilkins, O., Waldron, L., Nahal, H., Provart, N.J., Campbell, M.M. (2009).  Genotype and time of day shape the Populus drought response. The Plant Journal. 60, 703-715. Abstract
2006
Tuskan, G., Campbell, M., Douglas, C., Marra, M., Sandberg, G., Van de Peer, Y., Rokhsar, D. (2006).  The Genome of Black Cottonwood, Populus trichocarpa.. Science. 313(5793), 1596-1604. Abstract
2005
Dubos, C., Willment, J., Huggins, D., Grant, G., Campbell, M. (2005).  Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation.. The Plant Journal. 43, 348-355 doi:10.1111/ j.1365-313X.2005.02458.x. Abstract
Liang, Y., Dubos, C., Dodd, I., Holroyd, G., Hetherington, A., Campbell, M. (2005).  AtMYB61, an R2R3-MYB Transcription Factor Controlling Stomatal Aperture in Arabidopsis thaliana. Current Biology. 15, 1201-1206. Abstract
Rogers, L., Dubos, C., Surman, C., Willment, J., Cullis, I., Mansfield, S., Campbell, M. (2005).  Comparison of lignin deposition in three ectopic lignification mutants.. New Phytologist. 168, 123-140 doi:10.1111/j.1469-8137.2005.01496.x. Abstract
Rogers, L., Dubos, C., Cullis, I., Surman, C., Poole, M., Willment, J., Mansfield, S., Campbell, M. (2005).  Light, the circadian clock, and sugar perception in the control of lignin biosynthesis.. Journal of Experimental Botany. 56, 1651-1663 doi:10.1093/jxb/eri162. Abstract
Ingle, R., Mugford, S., Rees, J., Campbell, M., Smith, J. (2005).  Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants.. Plant Cell. 17, 2089-2106 doi:10.1105/tpc.104.030577. Abstract
2004
Rogers, L., Campbell, M. (2004).  Tansley Review: The genetic control of lignin deposition during plant growth and development.. New Phytologist. 164, 17-30 doi: 10.1111/ j.1469-8137.2004.01143.x. Abstract
Newman, L., Perazza, D., Juda, L., Campbell, M. (2004).  Involvement of the R2R3-MYB, AtMYB61, in the ectopic lignification and dark- photomorphogenic components of the det3 mutant phenotype.. The Plant Journal. 37, 239-250 doi:10.1046/j.1365-313X.2003.01953.x. Abstract
Smith, C., Rodriguez-Buey, M., Karlsson, J., Campbell, M. (2004).  The response of the poplar transcriptome to wounding and subsequent infection by a viral pathogen.. New Phytologist. 164, 123-136 doi: 10.1111/j.1469-8137.2004.01151.x. Abstract
Gó,, mez-Maldonado, J., Avila, C., de la Torre, F., Cañ,, as, R., Cá,, novas, F., Campbell, M. (2004).  Functional interactions between a glutamine synthetase promoter and MYB proteins.. The Plant Journal. 39, 513-526 doi:10.1111/j.1365-313X.2004.02153.x. Abstract
Smith, C., Campbell, M. (2004).  Complete genome sequence of poplar mosaic virus.. Archives of Virology. 149, 1831-1841 doi: 10.1007/ s00705-004-0348-2. Abstract
Smith, C., Campbell, M. (2004).  Populus genotypes differ in infection by, and systemic spread of, Poplar mosaic virus.. Plant Pathology. 53, 780-787 doi:10.1111/j.1365-3059.2004.01095.x. Abstract
2003
Campbell, M., Brunner, A., Jones, H., Strauss, S. (2003).  Forestry's Fertile Crescent: The application of biotechnology to forest trees.. Plant Biotechnology Journal. 1, 141-154. Abstract
Patzlaff, A., McInnis, S., Courtenay, A., Surman, C., Newman, L., Smith, C., Bevan, M., Mansfield, S., Sederoff RR, W.R., Campbell, M. (2003).  Characterisation of a pine MYB that regulates lignification.. The Plant Journal. 36, 743-754, doi:10.1046/ j.1365-313X.2003.01916.x. Abstract
Dubos, C., Huggins, D., Grant, G., Knight, M., Campbell, M. (2003).  A role for glycine in the gating of plant NMDA-like receptors.. The Plant Journal. 35, 800-810, doi: 10.1046/ j.1365-313X.2003.01849.x. Abstract
Patzlaff, A., Newman, L., Dubos, C., Whetten, R., Smith, C., McInnis, S., Bevan, M., Sederoff, R., Campbell, M. (2003).  Characterisation of PtMYB1, an R2R3-MYB from. Plant Molecular Biology. 53, 597-608 doi: 10.1023/ B:PLAN.0000019066.07933.d6. Abstract
2001
Strauss, S., Campbell, M., Pryor, S., Coventry, P., Burley, J. (2001).  Plantation Certification and Genetic Engineering: FSC's ban on research is counterproductive.. Journal of Forestry. 99, 04 .
Strauss, S., Coventry, P., Campbell, M., Pryor, S., Burley, J. (2001).  Certification of genetically modified forest plantations.. International Forestry Review. 3, 85-102. Abstract
Carpita, N., Tierney, M., Campbell, M. (2001).  Molecular biology of the plant cell wall: Searching for the genes that define structure, architecture and wall dynamics.. Plant Molecular Biology. 47, 01 .
2000
Mathews, J., Campbell, M. (2000).  The advantages and disadvantages of the application of genetic engineering to forest trees: a discussion.. Forestry. 73, 371-380.
1999
Newman, L., Campbell, M. (1999).  MYB proteins and xylem differentiation.. IN Cell and Molecular Biology of Wood Formation. Bios Academic Publishing. R.A. Savidge, J.R. Barnett, and R. Napier eds. 437-444.
Plomion, C., Hurme, P., Frigerio, J., Ridolfi, M., Pot, D., Pionneau, C., Avila, C., Gallardo, F., David, H., Neutelings, G., Campbell, M., Canovas FM, S.O., nè,, C, s. (1999).  Developing SSCP markers in two Pinus species.. Molecular Breeding. 5, 21-31.
Plomion, C., Hurme, P., Frigerio, J., Ridolfi, M., Pot, D., Pionneau, C., Avila, C., Gallardo, F., David, H., Neutelings, G., Campbell, M., Canovas FM, S.O., nè,, C, s. (1999).  Developing SSCP markers in two Pinus species.. Molecular Breeding. 5, 21-31.
1998
Allona, I, Quinn, M., Shoop, E., Swope, K., St. Cyr, S., Carlis, J., Riedl, J., Retzel, E., Campbell, M., Sederoff R, W.R. (1998).  Analysis of xylem formation in pine by cDNA sequencing.. Proc. Natl. Acad. Sci. USA. 95, 9693-9698.
1997
MacKay, J., O'Malley, D., Presnell, T., Booker, F., Campbell, M., Whetten, R., Sederoff, R. (1997).  Inheritance, gene expression and lignin charaterization. Proc. Natl. Acad. Sci. USA. 94, 8255-8260.
1996
Campbell, M., Sederoff, R. (1996).  Variation in lignin content and composition: mechanisms of control and implications for the genetic improvement of plants.. Plant Physiology. 110, 03 .
1994
Campbell, M., Whetten, R., Sederoff, R. (1994).  Cancer genes and wood. IN Proceedings of the 1994 TAPPI Biological Sciences Symposium.. 147-155.